Particle Swarm Optimization for Finding Efficient Longitudinal Exact Designs for Nonlinear Models
Volume 1, Issue 3 (2023), pp. 299–313
Pub. online: 10 August 2023
Type: Biomedical Research
Open Access
Accepted
13 May 2023
13 May 2023
Published
10 August 2023
10 August 2023
Abstract
Designing longitudinal studies is generally a very challenging problem because of the complex optimization problems. We show the popular nature-inspired metaheuristic algorithm, Particle Swarm Optimization (PSO), can find different types of optimal exact designs for longitudinal studies with different correlation structures for different types of models. In particular, we demonstrate PSO-generated D-optimal longitudinal studies for the widely used Michaelis-Menten model with various correlation structures agree with the reported analytically derived locally D-optimal designs in the literature when there are only 2 observations per subject, and their numerical D-optimal designs when there are 3 and 4 observations per subject. We further show the usefulness of PSO by applying it to generate new locally D-optimal designs to estimate model parameters when there are 5 or more observations per subject. Additionally, we find various optimal longitudinal designs for a growth curve model commonly used in animal studies and for a nonlinear HIV dynamic model for studying T-cells in AIDS subjects. In particular, c-optimal exact designs for estimating one or more functions of model parameters (c-optimality) were found, along with other types of multiple objectives optimal designs.
References
AbdelAziz, A. M., Alarabi, L., Basalamah, S. and Hendawi, A. (2021). A multi-objective optimization method for hospital admission problem – a case study on COVID-19 patients. Algorithms 14(2) 38. https://doi.org/10.3390/a14020038.
Butler, G. and Wolkowicz, G. (1985). A mathematical model of the chemostat with a general class of functions describing nutrient uptake. SIAM Journal on Applied Mathematics 45(1) 138–151. https://doi.org/10.1137/0145006. MR0775486
Cook, R. D. and Nachtsheim, C. J. (1980). A comparison of algorithms for constructing exact D-optimal designs. Technometrics 22(3) 315–324. https://doi.org/10.2307/1267577. MR0653111
Dette, H. and Kunert, J. (2014). Optimal designs for the Michaelis-Menten model with correlated observations. Statistics: A Journal of Theoretical and Applied Statistics 48(6) 1254–1267. https://doi.org/10.1080/02331888.2013.839680. MR3269733
Falco, I. D., Cioppa, A. D., Scafuri, U. and Tarantino, E. (2020). Coronavirus COVID-19 spreading in Italy: optimizing an epidemiological model with dynamic social distancing through Differential Evolution. arXiv preprint arXiv:2004.00553v3.
Fedorov, V. (1972). Theory of optimal design. Academic, New York. MR0403103
Haines, L. M. (1987). The application of the annealing algorithm to the construction of exact optimal designs for linear-regression models. Technometrics 29 439–447. MR2637962
Han, C., Chaloner, K. and Perelson, A. S. (2002). Bayesian analysis of a population HIV dynamic model. In Case Studies in Bayesian Statistics, editors: Constantine Gatsonis, Robert E. Kass, Alicia Carriquiry, Andrew Gelman, David Higdon, Donna K. Pauler and Isabella Verdinelli, Lecture Notes in Statistics: Vol. VI, 223–337. Springer. https://doi.org/10.1007/978-1-4612-2078-7_10. MR1959658
Lai, T. L., Choi, K. P., Tong, T. X. and Wong, W. K. (2021). A statistical approach to adaptive parameter tuning in nature-inspired optimization and optimal sequential design of dose-finding Trials. Statistica Sinica. In press. https://doi.org/10.5705/ss.20. MR4338089
Maloney, J. and Heidel, J. (2003). An analysis of a fractal kinetics curve of savageau. Anziam Journal 45 261–269. https://doi.org/10.1017/S1446181100013316. MR2017748
Tian, Y., Liu, R., Zhang, X., Ma, H., Tan, K. C. and Jin, Y. (2020). A multi-population evolutionary algorithm for solving large-scale multi-modal multi-objective optimization problems. IEEE Transactions on Evolutionary Computation. MR4361281
Tong, T. X., Choi, K. P., Lai, T. L. and Wong, W. K. (2021). Stability Bounds and Almost Sure Convergence of Improved Particle Swarm Optimization Methods. Research in Mathematical Sciences. https://doi.org/10.1007/s40687-020-00241-4. MR4257863
Whitacre, J. M. (2011). Recent trends indicate rapid growth of nature-inspired optimization in academia and industry. Computing 93 121–133. https://doi.org/10.1007/s00607-011-0154-z. MR2860177
Whitacre, J. M. (2011). Survival of the flexible: explaining the recent popularity of nature-inspired optimization within a rapidly evolving world. Computing 93 135–146. https://doi.org/10.1007/s00607-011-0156-x. MR2860178
Zhigljavsky, A., Dette, H. and Pepelyshev, A. (2010). A new approach to optimal design for linear models with correlated observations. Journal of the American Statistical Association 105 1093–1103. https://doi.org/10.1198/jasa.2010.tm09467. MR2752605