The New England Journal of Statistics in Data Science

The phase III BNT162b2 mRNA COVID-19 vaccine trial is based on a Bayesian design and analysis, and the main evidence of vaccine efficacy is presented in Bayesian statistics. Confusion and mistakes arise in the presentation of the Bayesian results. Some key statistics, such as Bayesian credible intervals, are mislabeled and stated as confidence intervals. Posterior probabilities of the vaccine efficacy are not reported as the main results. We illustrate the main differences in the reporting of Bayesian analysis results for a clinical trial and provide four recommendations. We argue that statistical evidence from a Bayesian trial, when presented properly, is easier to interpret and directly addresses the main clinical questions, thereby better supporting regulatory decision making. We also recommend using the abbreviation “BI” to represent Bayesian credible interval as a differentiation to “CI” which stands for confidence interval.

In this paper, we build a mechanistic system to understand the relation between a reduction in human mobility and Covid-19 spread dynamics within New York City. To this end, we propose a multivariate compartmental system that jointly models smartphone mobility data and case counts during the first 90 days of the epidemic. Parameter calibration is achieved through the formulation of a general statistical-mechanistic Bayesian hierarchical model. The open-source probabilistic programming language Stan is used for the requisite computation. Through sensitivity analysis and out-of-sample forecasting, we find our simple and interpretable model provides quantifiable evidence for how reductions in human mobility altered early case dynamics in New York City.